Titian's practice of building up successive layers of oil glazes on a red ground, to create a very rich, coloristic effect, was innovative and extremely influential. He started working with oil paints not so long after they had been adopted by other Venetian artists (such as Giovanni Bellini) from the northern Renaissance example, and he took them much further than his masters had done.
In general, though, Titian's loose, painterly, highly coloristic brushwork and movemented forms is considered to represent the quintessence of Venetian, or even just northern Italian style, as compared with more linear Florentine approaches in the 16th century. Ultimately, it was a combination of Titian's colorism with central Italian linearism and classicism that produced the Italian -- and European -- Baroque. A vast number of artists were influenced by Titian in the 16th, 17th, and 18th centuries and beyond: too many to list.